沈亚欧，女，博士，教授，博士生导师，国家万人计划青年拔尖人才、四川省杰出青年科技人才、四川省海外高层次留学人才。主要从事玉米遗传转化分子机理的理论及应用研究。先后主持5项国家自然科学基金、2项国家转基因重大专项子课题、1项973项目子课题等国家级项目及四川省杰出青年科技基金、四川省青年科技创新团队项目、四川省教育厅重点项目等省部级项目。近年来，以第一作者或通讯作者在《Trends in Biotechnology》、《PNAS》、《Plant Biotechnology Journal》等著名期刊发表论文30余篇，主研选育3个玉米新品种，主持选育4个高产高抗玉米基因工程新品系。以第一发明人获授权发明专利6项。
研究领域
玉米遗传转化分子机理的理论及应用研究
近5年科研情况
1. 玉米幼胚胚性愈伤组织诱导过程中重要miRNA及靶转录因子的功能研究，国家自然科学基金面上项目，2013.01-2016.12，主持；
2. 玉米幼胚胚性愈伤组织诱导能力全基因组遗传解析，国家自然科学基金面上项目，2015.01-2018.12，主持；
3. 玉米胚性愈伤组织再生能力的遗传基础及分子调控机制解析，2019.01-2022.12，主持；
4. 生长素信号传导途径ZmSAUR基因调控玉米幼胚诱导胚性愈伤组织能力的分子机制，2021.01-2024.12，主持；
5. 玉米IBM群体的产量性状全基因组遗传解析,国家973计划项目子课题，2014.01-2018.12，主持；
6. 玉米耐密、耐阴湿、大粒等相关基因的遗传转化和材料筛选，国家重大转基因专项子课题，2013.01-2015.12，主持；
7. 玉米耐密、耐阴湿、大粒等相关基因的遗传转化和材料筛选，国家重大转基因专项子课题，2016.01-2020.12，主持；
8. 玉米愈伤组织再生能力全基因组遗传解析,四川省杰出青年基金，2016.01-2018.12，主持；
9. 玉米胚性愈伤组织再生能力功能基因与分子调控机制研究,四川省青年科技创新团队项目，2021.04-2024.03，主持
10. 玉米胚乳蛋白质组平衡和优质蛋白玉米胚乳修饰机理研究，国家自然科学基金重大研究计划子项目，2014,01-2016,12，子课题主持
11. 近三年科研经费450万元，年均150万元。
曾获荣誉
1. 2013年入选四川省学术和技术带头人后备人选
2. 2016年入选四川省杰出青年科技人才
3. 2018年入选四川省海外高层次留学人才
4. 2020年入选国家万人计划青年拔尖人才
发表论文
1. Langlang Ma, Chuanyan Qing, Ursula Frei,Yaou Shen*, Thomas Lubberstedt*. Association mapping for root system architecture traits under two nitrogen conditions in germplasm enhancement of maize doubled haploid lines.Crop Journal, 2020, 8: 213-226.
2. Min Liu, Xiaolong Tan, Yan Yang, Peng Liu, Xiaoxiang Zhang, Yinchao Zhang, Lei Wang, Yu Hu, Langlang Ma, Zhaoling Li, Yanling Zhang, Chaoying Zou, Haijian Lin, Shibin Gao, Michael Lee, Thomas Lubberstedt, Guangtang Pan,Yaou Shen*. Analysis of the genetic architecture of maize kernel size traits by combined linkage and association mapping. Plant Biotechnology Journal, 2020,18: 207-221.
3. Xiaoxiang Zhang, Zhongrong Guan, Zhaoling Li, Peng Liu, Langlang Ma, Yinchao Zhang, Lang Pan, Shijiang He, Yanling Zhang, Peng Li, Fei Ge, Chaoying Zou, Yongcong He, Shibin Gao, Guangtang Pan,Yaou Shen*. A combination of linkage mapping and GWAS brings new elements on the genetic basis of yield‐related traits in maize across multiple environments.Thereotical and Applied Genetics, 2020, 133:2881-2895.
4. Yun Long,Yun Yang,Fei Ge,Guangtang Pan,Yaou Shen*. Establishment of a maize callus regeneration system from haploid shoot tips. Plant Cell,Tissue and Organ Culture, 2020, 141: 583-592.
5. Yanling Zhang, Tianhu Liang,Min Chen, Yinchao Zhang,Tao Wang, Haijian Lin,Tingzhao Rong, Chaoying Zou,Peng Liu, Michael Lee, Guangtang Pan,Yaou Shen*,Thomas Lübberstedt. Genetic dissection of stalk lodging‐related traits using an IBM Syn10 DH population in maize across three environments (Zea mays L.). Molecular Genetics and Genomics, 2019, 294:1277-1288.
6. Xiaoxiang Zhang, Zhongrong Guan, Lei Wang, Jun Fu, Yinchao Zhang, Zhaoling Li, Langlang Ma, Peng Liu, Yanling Zhang, Min Liu, Peng Li, Chaoying Zou, Yongcong He, Haijian Lin, Guangsheng Yuan, Shibin Gao, Guangtang Pan,Yaou Shen*. Combined GWAS and QTL analysis for dissecting the genetic architecture of kernel test weight in maize. Molecular Genetics and Genomics, 2019, 295: 409-420.
7. Xiaoling Zhang, Yanli Wang, Yuanyuan Yan, Hua Peng, Yun Long, Yinchao Zhang, Zhou Jiang, Peng Liu, Chaoying Zou, Huanwei Peng, Guangtang Pan,Yaou Shen*. BMC Genomics, 2019, 20:159.
8. Yanling Zhang, Peng Liu, Xiaoxiang Zhang, Qi Zheng, Min Chen, Fei Ge, Zhaoling Li, Wenting Sun, Zhongrong Guan, Tianhu Liang, Yan Zheng, Xiaolong Tan, Chaoying Zou, Huanwei Peng, Guangtang Pan,Yaou Shen*. Multi-locus genome-wide association study reveals the genetic architecture of stalk lodging resistance-related traits in maize. Frontiers in Plant Science, 2018, doi: 10.3389/fpls.2018.00611.
9. Langlang Ma†, Min Liu†, Yuanyuan Yan, Chunyan Qing, Xiaoling Zhang, Yanling Zhang, Yun Long, Lei Wang, Lang Pan, Chaoying Zou, Zhaoling Li, Yanli Wang, Huanwei Peng, Guangtang Pan, Zhou Jiang,Yaou Shen*. Genetic dissection of maize embryonic callus regenerative capacity using multi-locus genome-wide association studies. Frontiers in Plant Science, 2018, doi: 10.3389/fpls.2018.00561.
10. Langlang Ma, Zhongrong Guan, Zhiteng Zhang, Xiaoxiang Zhang, Yanling Zhang, Chaoying Zou, Huanwei Peng, Guangtang Pan, Michael Lee,Yaou Shen*, Thomas Lubberstedt. Identification of quantitative trait loci for leaf-related traits in an IBM Syn10 DH maize population across three environments, Plant Breeding, 2018,137(2): 127-138.
11. Fei Ge, Hongmei Hu, Xing Huang, Yanling Zhang, Yanli Wang, Zhaoling Li, Chaoying Zou, Huanwei Peng, Lujiang Li, Shibin Gao, Guangtang Pan,Yaou Shen*. Metabolomic and proteomic analysis of maize embryonic callus induced from immature embryo. Scientific Reports, 2017, 7: 1004.
12. Hongjun Liu, Langlang Ma, Xuerong Yang, Lin Zhang, Xing Zeng, Shupeng Xie, Huanwei Peng, Shibin Gao, Haijian Lin, Guangtang Pan, Yongrui Wu,Yaou Shen*. Integrative analysis of DNAs during maize embryo dedifferentiation. BMC Plant Biology, 2017, 17:105.
13. Yanling Zhang, Fei Ge, Fengxia Hou, Wenting Sun, Qi Zheng, Xiaoxiang Zhang, Langlang Ma, Jun Fu, Xiujing He, Huanwei Peng, Guangtang Pan,Yaou Shen*. Transcription factors responding to Pb stess in maize. Genes, 2017, 8: 231.
14. Fei Ge, Xing Huang, Hongmei Hu, Yanling Zhang, Yanli Wang, Zhaoling Li, Chaoying Zou, Huanwei Peng, Lujiang Li, Shibin Gao, Guangtang Pan,Yaou Shen*. Endogenous small interfering RNAs associated with maize embryonic callus formation. PLoS One, 2017, e0180567.
15. Fei Ge, Xu Luo, Xing Huang, Yanling Zhang, Xiujing He, Min Liu, Haijian Lin, Huanwei Peng, Lujiang Li, Zhiming Zhang, Guangtang Pan*,Yaou Shen*. Genome-wide analysis of transcription factors involved in maize embryonic callus formation. Physiologia Plantarum, 2016,158(4): 452-462.
16.Yaou Shen*, Guangtang Pan, Thomas Lubberstedt*. Haploid strategies for functional validation of plant genes. Trends in Biotechnology, 2015, 33(10): 611-620.
17. Cheng Qin#, Changshui Yu#,Yaou Shen#, Xiaodong Fang, Lang Chen, Jiumeng Min, Ye Yin, Jiping Yu, Kailin Hu, and Zhiming Zhang* et al. Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization. PNAS, 2014, 111(14): 5135-5140.
18.Yaou Shen, Zhou Jiang, Xiadong Yao, Zhiming Zhang, Haijian Lin, Maojun Zhao, Hailan Liu, Huanwei Peng, Shujun Li, Guangtang Pan*. Genome expression profile analysis of the immature maize embryo during dedifferentiation, PLoS One, 2012, 7(3): e32237.
19.Yaou Shen, Zhiming Zhang, Haijian Lin, Hailan Liu, Jie Chen, Hua Peng, Moju Cao, Tingzhao Rong, Guangtang Pan*. Cytoplasmic male sterility-regulated novel microRNAs from maize. Funct Integr Genomics, 2011, 11(1): 179-191.
20.Yaou Shen, Yongzhong Zhang, Jie Chen, Haijian Lin, Maojun Zhao, Huanwei Peng, Li Liu, Guangsheng Yuan, Zhiming Zhang, Suzhi Zhang, Guangtang Pan*. Genome expression profile analysis reveals important transcripts in maize roots responding to the stress of heavy metal Pb. Phyisologia Plantarum, 2013,147: 270-282.
21.Yaou Shen,Zhou Jiang, Sifen Lu, Haijian Lin, Shibin Gao, Huanwei Peng, Guangsheng Yuan, Li Liu, Zhiming Zhan, Maojun Zhao, Tingzhao Rong, Guangtang Pan*. Combined small RNA and degradome sequencing reveals microRNA regulation during immature maize embryo dedifferentiation. BBRC, 2013,441:425-430.
22.Yaou Shen,Shujun Li,Zhou Jiang, Langlang Ma, Haijian Lin, Huanwei Peng,Li Liu, Guangsheng Yuan, Maojun Zhao,Shibin Gao,Zhiming Zhang,Guangtang Pan*. Overexpression of an Incw2 gene in endosperm improved yield-related traits in maize.Maydica, 2012, 57: 147-153.
23.Yaou Shen, Hongning Wang, Guangtang Pan*. Improving Inorganic Phosphorus Content in Maize Seeds by Introduction of Phytase Gene. Biotechnology, 2008, 7(2): 323-327.
24.Yaou Shen, Yongzhong Zhang, Haijian Lin, Shibin Gao, Guangtang Pan*. Effect of low phosphorus stress on endogenous hormone levels of different maize genotypes in seedling stage. Journal of Biological Sciences, 2012,12(5):308-314.
25. Fei Ge, Maojun Zhao, Haijian Lin, Guangtang Pan and Yaou Shen*. Study on the Growth Inhibition Ratio of Rhizoctonia Solani Controlled by Nano-Al2O3/TiO2. Journal of Food Agriculture & Environment2014(12)2: 1168-1171.
26. Junqiu Luo, Huanwei Peng,Yaou Shen*.Interorgan metabolism of nitrogen in nonruminants. Journal of Food, Agriculture & Environment, 2012, 10(2): 598-602.
27.沈亚欧，李淑君，林海建，张志明，江舟，何晶，潘光堂*.通过转基因手段改善作物产量性状.农业生物技术学报, 2011, 19(4): 753-726.
28.沈亚欧，林海建，张志明，高世斌，潘光堂*.植物逆境miRNA研究进展.遗传, 2009, 31(3): 227-235.
29.沈亚欧，彭焕伟，潘光堂*.转基因植物表达植酸酶的研究进展.中国生物工程杂志, 2005, 25(1): 25-32.
30. 张晓玲，龙芸，葛飞，管中荣，张晓祥，王艳丽，沈亚欧*，潘光堂*. 玉米幼胚胚性愈伤组织再生能力相关性状遗传研究.遗传, 2017, 39(2): 143-155.
31. 马浪浪，江舟，黄小波，沈亚欧*，潘光堂.植物DNA甲基化调控研究进展.中国生物工程杂志, 2013, 33(9): 101-110.
32. 吴花拉，张严玲，罗旭，葛飞，潘光堂，沈亚欧*.位点特异性重组系统及其在植物转基因研究中的应用.中国生物工程杂志, 2014, 34(11): 107-118.
33. 杨珊,王静,李清超,刘丽,张志明,潘光堂,沈亚欧*.玉米自交系K10白色叶鞘遗传机理研究.植物遗传资源学报, 2014, 15(6): 1167-1172.
34. Hailan Liu, Yueai Lin, Guobo Chen,Yaou Shen, Jian Liu and Suzhi Zhang*. Genome-scale identification of resistance gene analogs and the development of their intron length polymorphism markers in maize.MolecularBreeding, 2011, 29: 437-447.
35. Fei Zheng, Guiqin Mu, Zhiming Zhang,Yaou Shen, Maojun Zhao, Guangtang Pan*. Nitrogen-doped hollow macroprous carbon spheres with high electrocatalytic activity for oxygen reduction. Materials Letters, 2011, 68: 453-456.
36. Meng Xu, Yunsong Zhang, Zhiming Zhang,Yaou Shen, Maojun Zhao, Guangtang Pan*. Study on the adsorption of Ca2+. Cd2+ and Pb2+ by magnetic Fe3O4 yeast treated withEDTA dianhydride. Chemical Engineering Journal, 2011, 168: 737-745.
37. Hongjun Liu, Xuerong Yang,Yaou Shen, Haijian Lin, Thomas Lübberstedt, Zhiming Zhang, Guangtang Pan*. Genome-wide comparative analysis of digital gene expression tag profiles during maize ear development.Genomics, 2015, 106(1): 52-60.
38. Fuqiang Yin, Cheng Qin, Jian Gao, Ming Liu, Xirong Luo, Wenyou Zhang, Hongjun Liu, Xinhui Liao,Yaou Shen, Likai Mao, Zhiming Zhang, Haijian Lin, Thomas Lübberstedt, and Guangtang Pan*. Genome-Wide Identification and Analysis of Drought-Responsive Genes and MicroRNAs in Tobacco. Int. J. Mol. Sci., 2015, 16:5714-5740.
39. Jian Gao, Yongzhong Zhang, Chaolong Lu, Hua Peng, Mao Luo, Gaoke Li,Yaou Shen, Haiping Ding, Zhiming Zhang, Guangtang Pan*, Haijian Lin*. The development dynamics of the maize root transcriptome responsive to heavy metal Pb pollution. Biochemical and Biophysical Research Communications, 2015, 458(2): 287-293.
40. Haiping Ding, Jian Gao, Cheng Qin, Haixia Ma, Hong Huang, Pan Song, Xirong Luo, Haijian Lin,Yaou Shen, Guangtang Pan* and Zhiming Zhang*. The Dynamics of DNA Methylation in Maize Roots under Pb Stress. Int. J. Mol. Sci., 2014, 15, 23537-23554.
41. Hongjun Liu, Cheng Qin, Zhe Chen, Tao Zuo, Xuerong Yang, Huangkai Zhou, Meng Xu, Shiliang Cao,Yaou Shen, Haijian Lin, Xiujing He, Yinchao Zhang, Lujiang Li, Haiping Ding, Thomas Lübberstedt, Zhiming Zhang*, Guangtang Pan*. Identification of miRNAs and their target genes in developing maize ears by combined small RNA and degradome sequencing. BMC Genomics, 2014, 15:25.
42. Jian Gao, Zhe Chen, Mao Luo, Hua Peng, Haijian Lin, Cheng Qin, Guangsheng Yuan,Yaou Shen, Haiping Ding, Maojun Zhao, Guangtang Pan*, Zhiming Zhang*. Genome expression profile analysis of the maize sheath in response to inoculation to R. solani. Mol Biol Rep, 2014, 41: 2471-2483.
43. Haiping Ding, Cheng Qin, Xirong Luo, Lujiang Li, Zhe Chen, Hongjun Liu, Jian Gao, Haijian Lin,Yaou Shen, Maojun Zhao, Thomas Lübberstedt, Zhiming Zhang*, and Guangtang Pan*. Heterosis in early maize ear inflorescence development: A genome-wide transcription analysis for two maize inbred lines and their hybrid. Int J Mol Sci, 2014, 15:13892-13915.
44. Su Shunzong, Wu Ling, Liu Dan, Lu Yanli, Lin Haijian, Zhang Shuzhi,Shen Yaou, Liu Hailan, Zhang Zhiming, Rong Tingzhao, Zhang Xiao, Tian Yuehui, Nie Zhi, Gao Shibin*. Genome-wide expression profile of maize root response to phosphorus deficiency revealed by deep sequencing. Journal of Integrative Agriculture, 2014, 13(6): 1216-1229.
45. Haiping Ding, Jian Gao, Mao Luo, Hua Peng, Haijian Lin, Guangsheng Yuan,Yaou Shen, Maojun Zhao, Guangtang Pan*, Zhiming Zhang*. Identification and functional analysis of miRNAs in developing kernels of a viviparous mutant in maize. The Crop Journal, 2013, 1(2): 115-126.
46. Guangsheng Yuan, Zhiming Zhang, Kui Xiang,Yaou Shen, Juan Du, Haijian Lin & Li Liu, Maojun Zhao, Guangtang Pan*. Different Gene Expressions of Resistant and Susceptible Maize Inbreds in Response to Fusarium verticillioides Infection.Plant Mol Biol Rep, 2013, 31: 925-935.
47. Guang-Sheng Yuan, Kui Xiang, Zhi-Ming Zhang,Ya-Ou Shen, Juan Du, Hai-Jian Lin, Li Liu and Guang-Tang Pan*. Analysis on the relationship between Fusarium verticillioides infection-induced genes and ear rot resistance in maize. Journal: Food, Agriculture and Environment, 2013, 11(2): 363-366.
48. Zhiming Zhang, Jin Feng, Cui Wang, Jun Luo, Haijian Lin, Kui Xiang, Li Liu, Maojun Zhao, Yunsong Zhang, Haiping Ding, Shufeng Zhou,Yaou Shenand Guangtang Pan*. Difference between Pb and Cd Accumulation in 19 Elite Maize Inbred Lines and Application Prospects. Journal of Biomedicine and Biotechnology, 2012, 2012: 271485.
49. Zhiming Zhang, Haijian Lin,Yaou Shen, Jian Gao, Kui Xiang, Li Liu, Haiping Ding, Guangsheng Yuan, Hai Lan, Shufeng Zhou, Maojun Zhao, Shibin Gao, Tingzhao Rong, Guangtang Pan*. Cloning and characterization of miRNAs from maize seedling roots under low phosphorus stress. Molecular biology report, 2012, 39: 8137-8146.
50. Yuan Guangsheng, Zhang Zhiming, Xiang Kui, Zhao Maojun,Shen Yaou, Pan Guangtang*. Large-scale identification of differentially expressed genes in maize inbreds susceptible and resistant to Fusarium ear rot. Plant Omics Journal, 2012, 9(5): 471-475.
51. Hongjun Liu,Huangkai Zhou ,Yongsheng Wu ,Xiao Li, Jing Zhao, Tao Zuo, Xuan Zhang, Yongzhong Zhang, Sisi Liu,Yaou Shen, Haijian Lin, Zhiming Zhang, Kaijian Huang,Thomas Lübberstedt,Guangtang Pan*. The Impact of Genetic Relationship and Linkage Disequilibrium on Genomic Selection. PLoS One, 10(7): e0132379.
联系方式
常用邮箱:shenyaou@aliyun.com
